No but I have a lot of friends who have and my dad has participated in a lot of trials over the years for asthma medication. One friend are radioactive porridge for six weeks and another had her eggs collected and frozen, one trialled using chemotherapy to treat psoriasis and another was a guinea pig for a new approach to treating breast cancer. apart from the first two, all the others (including my dad) had reached a point with their condition where the doctors said they could either try the new medicine or just accept that they would die. Luckily for all of them, the new drugs were effective :)